Interaction of a vortex induced by a rotating cylinder with a plane

In this article,we study theoretically and numerically the interaction of a vortex induced by a rotating cylinder with a perpendicular plane. We show the existence of weak solutions to the swirling vortex models by using the Hopf extension method, and by an elegant contradiction argument, respectively. We demonstrate numerically that the model could produce phenomena of swirling vortex including boundary layer pumping and two-celled vortex that are observed in potential line vortex interacting with a plane and in a tornado

Evolutionary Multiagent Transfer Learning With Model-Based Opponent Behavior Prediction

This article embarks a study on multiagent transfer learning (TL) for addressing the specific challenges that arise in complex multiagent systems where agents have different or even competing objectives. Specifically, beyond the essential backbone of a state-of-the-art evolutionary TL framework (eTL), this article presents the novel TL framework with prediction (eTL-P) as an upgrade over existing eTL to endow agents with abilities to interact with their opponents effectively by building candidate models and accordingly predicting their behavioral strategies. To reduce the complexity of candidate models, eTL-P constructs a monotone submodular function, which facilitates to select Top-K models from all available candidate models based on their representativeness in terms of behavioral coverage as well as reward diversity. eTL-P also integrates social selection mechanisms for agents to identify their better-performing partners, thus improving their learning performance and reducing the complexity of behavior prediction by reusing useful knowledge with respect to their partners' mind universes. Experiments based on a partner-opponent minefield navigation task (PO-MNT) have shown that eTL-P exhibits the superiority in achieving higher learning capability and efficiency of multiple agents when compared to the state-of-the-art multiagent TL approaches

Media Literasi: Upaya Bijak Menyikapi Terpaan Tayangan Televisi

The television media have transformed into industry. Tight competition among TV stations demands the media people to provide programs based on the market taste. Therefore, mostly TV stations design and produce their programs based on share and rating numbers, instead of quality. On the other side, TV stations have important roles in constructing social and cultural development. Currently, TV programs are merely produced based on the business orientation so that the quality of the TV programs is often ignored. Audience must be wise and smart to protect themselves from poor-quality TV programs exposure. This can be achieved by improving their Media Literacy. In the end, Audience is no longer treated as passive object, but actively takes control on the content selection

Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis

<p>Abstract</p> <p>Background</p> <p>As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer risks, but previous results have been conflicting.</p> <p>Methods</p> <p>We preformed a meta-analysis using 22 eligible case-control studies (including 32 datasets) with a total of 11,273 patients and 13,179 controls to summarize the existing data on the association between the <it>CTLA-4 </it>+49G > A polymorphism and cancer risk.</p> <p>Results</p> <p>Compared with the common <it>CTLA-4 </it>+49G > A GG genotype, the carriers of variant genotypes (<it>CTLA-4 </it>+49 GC/CC) had a 1.24-fold elevated risk of cancer (95% CI = 1.18-1.32, <it>P </it>< 0.05) under the dominant genetic model, as estimated using a fixed effect model. The effect of the <it>CTLA-4 </it>+49G > A polymorphism was further evaluated using stratification analysis. In four breast cancer studies, patients with the variant genotypes had a significantly increased risk of breast cancer (OR = 1.31, 95% CI = 1.17-1.48, <it>P </it>< 0.00001). A similar result was found in three skin cancer studies (OR = 1.30, 95% CI = 1.10-1.52, <it>P </it>= 0.001). In 26 solid tumor studies, subjects with the variant genotypes had a significantly higher risk of developing solid tumors (OR = 1.25, 95% CI = 1.18-1.33, <it>P </it>< 0.00001) compared with the 6 non-solid tumor studies (OR = 1.08, 95% CI = 0.79-1.48, <it>P </it>= 0.62). Patients with variant genotypes had significantly increased risk of non-epithelial tumors and epithelial tumors, with ORs of 1.23 (95% CI = 1.14-1.32, <it>P </it>< 0.00001) and 1.29 (95% CI = 1.17-1.41, <it>P </it>< 0.00001), respectively. It was also demonstrated that the increased risk of cancer associated with <it>CTLA-4 </it>+49G > A variant genotypes was more pronounced in Caucasians (OR = 1.29, 95% CI = 1.13-1.47, <it>P </it>= 0.0002), Asians (OR = 1.23, 95% CI = 1.16-1.32, <it>P </it>< 0.00001) and Chinese (OR = 1.23, 95% CI = 1.15-1.31, <it>P </it>< 0.00001).</p> <p>Conclusion</p> <p>Our meta-analysis suggests that the <it>CTLA-4 </it>+49G > A polymorphism genotypes (GA + AA) might be associated with an increased risk of cancer, especially in Caucasians and Chinese.</p

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10−20) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10−13). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10−10). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region

On Korn’s inequalities on a surface

International audienceKorn’s inequalities on a surface constitute the keystone for establishing the existence and uniqueness of solutions to various linearly elastic shell problems. As a rule, they are, however, somewhat delicate to establish. After briefly reviewing how such Korn inequalities are classically established, we show that they can be given simpler and more direct proofs in some important special cases, without any recourse to J. L. Lions lemma; besides, some of these inequalities hold on open sets that are only assumed to be bounded. In particular, we establish a new “identity for vector fields defined on a surface”. This identity is then used for establishing new Korn’s inequalities on a surface, whose novelty is that only the trace of the linearized change of curvature tensor appears in their right-hand side

New identity and Korn’s inequalities on a surface

International audienceWe establish an identity satisfied by smooth-enough vector fields defined on a surface S ⊂ R3 with values in R3 . As consequences of this identity, we establish several new Korn inequalities for vector fields that vanish on the entire boundary of this surface

theanisotropyoffreepathinavibrofluidizedgranulargas

The free path of a vibro-fluidized two-dimensional (2D) inelastic granular gas confined in a rectangular box is investigated by 2D event-driven molecular simulation. By tracking particles in the simulation, we analyze the local free path. The probability distribution of the free path shows a high tail deviating from the exponential prediction. The anisotropy of the free path is found when we separate the free path to x and y components. The probability distribution of y component is exponential, while x component has a high tail. The probability distribution of angle between the relative velocity and the unit vector joined two particle centers deviates from the distribution of two random vectors, indicating the existence of the dynamic heterogeneities in our system. We explain these results by resorting to the kinetic theory with two-peak velocity distribution. The kinetic theory agrees well with the simulation result